Altered brain-wide auditory networks in a zebrafish model of fragile X syndrome.

ABSTRACT:

Background

Loss or disrupted expression of the FMR1 gene causes fragile X syndrome (FXS), the most common monogenetic form of autism in humans. Although disruptions in sensory processing are core traits of FXS and autism, the neural underpinnings of these phenotypes are poorly understood. Using calcium imaging to record from the entire brain at cellular resolution, we investigated neuronal responses to visual and auditory stimuli in larval zebrafish, using fmr1 mutants to model FXS. The purpose of this study was to model the alterations of sensory networks, brain-wide and at cellular resolution, that underlie the sensory aspects of FXS and autism.

Results

Combining functional analyses with the neurons' anatomical positions, we found that fmr1^-/- animals have norma

SUBMITTER: Constantin L 

PROVIDER: S-EPMC7493858 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature