Alterations in gene expression in the spinal cord of mice lacking Nfix.

ABSTRACT:

Objective

Nuclear Factor One X (NFIX) is a transcription factor expressed by neural stem cells within the developing mouse brain and spinal cord. In order to characterise the pathways by which NFIX may regulate neural stem cell biology within the developing mouse spinal cord, we performed an microarray-based transcriptomic analysis of the spinal cord of embryonic day (E)14.5 Nfix^-/- mice in comparison to wild-type controls.

Data description

Using microarray and differential gene expression analyses, we were able to identify differentially expressed genes in the spinal cords of E14.5 Nfix^-/- mice compared to wild-type controls. We performed microarray-based sequencing on spinal cords from n = 3 E14.5 Nfix^-/- mice and n = 3 E14.5 Nfix^+/+</

SUBMITTER: Matuzelski E 

PROVIDER: S-EPMC7493862 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature