Entamoeba and Giardia parasites implicated as hosts of CRESS viruses.

ABSTRACT: Metagenomic techniques have enabled genome sequencing of unknown viruses without isolation in cell culture, but information on the virus host is often lacking, preventing viral characterisation. High-throughput methods capable of identifying virus hosts based on genomic data alone would aid evaluation of their medical or biological relevance. Here, we address this by linking metagenomic discovery of three virus families in human stool samples with determination of probable hosts. Recombination between viruses provides evidence of a shared host, in which genetic exchange occurs. We utilise networks of viral recombination to delimit virus-host clusters, which are then anchored to specific hosts using (1) statistical association to a host organism in clinical samples, (2) endogenous viral ele

SUBMITTER: Kinsella CM 

PROVIDER: S-EPMC7493932 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature