Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease.

ABSTRACT:

Background

Increased physical exercise improves cognitive function and reduces pathology associated with Alzheimer's disease (AD). However, the mechanisms underlying the beneficial effects of exercise in AD on the level of specific brain cell types remain poorly investigated. The involvement of astrocytes in AD pathology is widely described, but their exact role in exercise-mediated neuroprotection warrant further investigation. Here, we investigated the effect of long-term voluntary physical exercise on the modulation of the astrocyte state.

Methods

Male 5xFAD mice and their wild-type littermates had free access to a running wheel from 1.5 to 7 months of age. A battery of behavioral tests was used to assess the effects of voluntary exercise on cognition and learning. Neuron

SUBMITTER: Belaya I 

PROVIDER: S-EPMC7493971 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature