Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation.

ABSTRACT:

Background

The three-dimensional genome organization is critical for gene regulation and can malfunction in diseases like cancer. As a key regulator of genome organization, CCCTC-binding factor (CTCF) has been characterized as a DNA-binding protein with important functions in maintaining the topological structure of chromatin and inducing DNA looping. Among the prolific binding sites in the genome, several events with altered CTCF occupancy have been reported as associated with effects in physiology or disease. However, hitherto there is no comprehensive survey of genome-wide CTCF binding patterns across different human cancers.

Results

To dissect functions of CTCF binding, we systematically analyze over 700 CTCF ChIP-seq profiles across human tissues and cancers and identif

SUBMITTER: Fang C 

PROVIDER: S-EPMC7493976 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature