NAD⁺ in Aging: Molecular Mechanisms and Translational Implications.

ABSTRACT: The coenzyme NAD⁺ is critical in cellular bioenergetics and adaptive stress responses. Its depletion has emerged as a fundamental feature of aging that may predispose to a wide range of chronic diseases. Maintenance of NAD⁺ levels is important for cells with high energy demands and for proficient neuronal function. NAD⁺ depletion is detected in major neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, cardiovascular disease and muscle atrophy. Emerging evidence suggests that NAD⁺ decrements occur in various tissues during aging, and that physiological and pharmacological interventions bolstering cellular NAD⁺ levels might retard aspects of aging and forestall some age-related diseases. Here, we discuss aspects of

SUBMITTER: Fang EF 

PROVIDER: S-EPMC7494058 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature