Spatial spillover analysis of a cluster-randomized trial against dengue vectors in Trujillo, Venezuela.

ABSTRACT:

Background

The ability of cluster-randomized trials to capture mass or indirect effects is one reason for their increasing use to test interventions against vector-borne diseases such as malaria and dengue. For the same reason, however, the independence of clusters may be compromised if the distances between clusters is too small to ensure independence. In other words they may be subject to spillover effects.

Methods

We distinguish two types of spatial spillover effect: between-cluster dependence in outcomes, or spillover dependence; and modification of the intervention effect according to distance to the intervention arm, or spillover indirect effect. We estimate these effects in trial of insecticide-treated materials against the dengue mosquito vector, Aedes aegypti, in Ve

SUBMITTER: Alexander N 

PROVIDER: S-EPMC7494074 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature