Biomaterials functionalized with MSC secreted extracellular vesicles and soluble factors for tissue regeneration.

ABSTRACT: The therapeutic benefits of mesenchymal stromal cell (MSC) transplantation have been attributed to their secreted factors, including extracellular vesicles (EVs) and soluble factors. The potential of employing the MSC secretome as an alternative acellular approach to cell therapy is being investigated in various tissue injury indications, but EVs administered via bolus injections are rapidly sequestered and cleared. However, biomaterials offer delivery platforms to enhance EV retention rates and healing efficacy. In this review, we highlight the mechanisms underpinning the therapeutic effects of MSC-EVs and soluble factors as effectors of immunomodulation and tissue regeneration, conferred primarily via their nucleic acid and protein contents. We discuss how manipulating the cell culture m

SUBMITTER: Brennan MA 

PROVIDER: S-EPMC7494127 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature