Ontology highlight
ABSTRACT:
SUBMITTER: Brennan MA
PROVIDER: S-EPMC7494127 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Brennan Meadhbh Á MÁ Layrolle Pierre P Mooney David J DJ
Advanced functional materials 20200311 37
The therapeutic benefits of mesenchymal stromal cell (MSC) transplantation have been attributed to their secreted factors, including extracellular vesicles (EVs) and soluble factors. The potential of employing the MSC secretome as an alternative acellular approach to cell therapy is being investigated in various tissue injury indications, but EVs administered via bolus injections are rapidly sequestered and cleared. However, biomaterials offer delivery platforms to enhance EV retention rates and ...[more]