Clinically Precedented Protein Kinases: Rationale for Their Use in Neurodegenerative Disease.

ABSTRACT: Kinases are an intensively studied drug target class in current pharmacological research as evidenced by the large number of kinase inhibitors being assessed in clinical trials. Kinase-targeted therapies have potential for treatment of a broad array of indications including central nervous system (CNS) disorders. In addition to the many variables which contribute to identification of a successful therapeutic molecule, drug discovery for CNS-related disorders also requires significant consideration of access to the target organ and specifically crossing the blood-brain barrier (BBB). To date, only a small number of kinase inhibitors have been reported that are specifically designed to be BBB permeable, which nonetheless demonstrates the potential for success. This review considers the poten

SUBMITTER: Benn CL 

PROVIDER: S-EPMC7494159 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature