Differential transcription of expanded gene families in central carbon metabolism of Streptomyces coelicolor A3(2).

ABSTRACT:

Background

Streptomycete bacteria are prolific producers of specialized metabolites, many of which have clinically relevant bioactivity. A striking feature of their genomes is the expansion of gene families that encode the same enzymatic function. Genes that undergo expansion events, either by horizontal gene transfer or duplication, can have a range of fates: genes can be lost, or they can undergo neo-functionalization or sub-functionalization. To test whether expanded gene families in Streptomyces exhibit differential expression, an RNA-Seq approach was used to examine cultures of wild-type Streptomyces coelicolor grown with either glucose or tween as the sole carbon source.

Results

RNA-Seq analysis showed that two-thirds of genes within expanded gene familie

SUBMITTER: Schniete JK 

PROVIDER: S-EPMC7494193 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature