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Emergence of ST15 Klebsiella pneumoniae Clinical Isolates Producing Plasmids-Mediated RmtF and OXA-232 in China.

ABSTRACT: Background:RmtF, as 16S rRNA methyltransferase, leads to high-level resistance to aminoglycoside and is now barely reported. Methods and Results:Three rmtF-positive Klebsiella pneumoniae isolates, belonging to the pandemic clone sequence type 15, were isolated from children and coproduced bla OXA-232 and bla CTX-M-15. The rmtF gene was located on an IncFIB transformable plasmid of 128,536-bp and bla OXA-232 was on a 6141-bp ColKP3 plasmid, respectively. Conclusion:Plasmids with rmtF found worldwide, shared relatively low similarity, and merely matched partly in their multidrug resistance region. Notably, clinical isolates coproducing rmtF and bla OXA-232 are gradually increasing in China.

SUBMITTER: Shi Q 

PROVIDER: S-EPMC7494224 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Emergence of ST15 <i>Klebsiella pneumoniae</i> Clinical Isolates Producing Plasmids-Mediated RmtF and OXA-232 in China.

Shi Qingyu Q   Han Renru R   Guo Yan Y   Zheng Yonggui Y   Yang Yang Y   Yin Dandan D   Zhang Rong R   Hu Fupin F  

Infection and drug resistance 20200911

<h4>Background</h4>RmtF, as 16S rRNA methyltransferase, leads to high-level resistance to aminoglycoside and is now barely reported.<h4>Methods and results</h4>Three <i>rmtF</i>-positive <i>Klebsiella pneumoniae</i> isolates, belonging to the pandemic clone sequence type 15, were isolated from children and coproduced <i>bla</i> <sub>OXA-232</sub> and <i>bla</i> <sub>CTX-M-15</sub>. The <i>rmtF</i> gene was located on an IncFIB transformable plasmid of 128,536-bp and <i>bla</i> <sub>OXA-232</sub>  ...[more]

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