Emergence of ST15 Klebsiella pneumoniae Clinical Isolates Producing Plasmids-Mediated RmtF and OXA-232 in China.

ABSTRACT:

Background

RmtF, as 16S rRNA methyltransferase, leads to high-level resistance to aminoglycoside and is now barely reported.

Methods and results

Three rmtF-positive Klebsiella pneumoniae isolates, belonging to the pandemic clone sequence type 15, were isolated from children and coproduced bla _OXA-232 and bla _CTX-M-15. The rmtF gene was located on an IncFIB transformable plasmid of 128,536-bp and bla _OXA-232 was on a 6141-bp ColKP3 plasmid, respectively.

Conclusion

Plasmids with rmtF found worldwide, shared relatively low similarity, and merely matched partly in their multidrug resistance region. Notably, clinical isolates coproducing rmtF and bla _OXA-232 are grad

SUBMITTER: Shi Q 

PROVIDER: S-EPMC7494224 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature