Humoral Immune Response to SARS-CoV-2 in Iceland.

ABSTRACT:

Background

Little is known about the nature and durability of the humoral immune response to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Methods

We measured antibodies in serum samples from 30,576 persons in Iceland, using six assays (including two pan-immunoglobulin [pan-Ig] assays), and we determined that the appropriate measure of seropositivity was a positive result with both pan-Ig assays. We tested 2102 samples collected from 1237 persons up to 4 months after diagnosis by a quantitative polymerase-chain-reaction (qPCR) assay. We measured antibodies in 4222 quarantined persons who had been exposed to SARS-CoV-2 and in 23,452 persons not known to have been exposed.

Results

Of the 1797 persons who had recovered from SARS-CoV-2 infec

SUBMITTER: Gudbjartsson DF 

PROVIDER: S-EPMC7494247 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature