Exposure-response assessment of cancer mortality in styrene-exposed boatbuilders.

ABSTRACT:

Objectives

To improve exposure estimates and reexamine exposure-response relationships between cumulative styrene exposure and cancer mortality in a previously studied cohort of US boatbuilders exposed between 1959 and 1978 and followed through 2016.

Methods

Cumulative styrene exposure was estimated from work assignments and air-sampling data. Exposure-response relationships between styrene and select cancers were examined in Cox proportional hazards models matched on attained age, sex, race, birth cohort and employment duration. Models adjusted for socioeconomic status (SES). Exposures were lagged 10 years or by a period maximising the likelihood. HRs included 95% profile-likelihood CIs. Actuarial methods were used to estimate the styrene exposure corresponding to 10^-4

SUBMITTER: Daniels RD 

PROVIDER: S-EPMC7494518 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature