NMR structure of Dengue West Nile viruses stem-loop B: A key cis-acting element for flavivirus replication.

ABSTRACT: Flaviviruses are major emerging human pathogenic viruses that pose a persistent and growing menace to global health. They are enveloped single-stranded RNA viruses with positive polarity transmitted by arthropod vectors like mosquitoes or ticks, responsible for a significant and growing number of human deaths and illnesses. The 5'- and 3'-untranslated regions (UTRs) are highly structured and contain conserved cis-acting RNA elements that participate in viral translation, replication and host adaptation. Despite their role in fiaviviruses replication, few high-resolution structural studies have investigated the RNA elements required for viral replication. Here we report the NMR structures of stem-loop B from WNV and DENV4 viruses. Because this element is required for cyclization of the geno

SUBMITTER: Sharma S 

PROVIDER: S-EPMC7494574 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature