Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity.

ABSTRACT:

Background

General anesthetics influence mitochondrial homeostasis, placing individuals with mitochondrial disorders and possibly carriers of recessive mitochondrial mutations at increased risk of perioperative complications. In Drosophila, mutations in the ND23 subunit of complex I of the mitochondrial electron transport chain-analogous to mammalian NDUFS8-replicate key characteristics of Leigh syndrome, an inherited mitochondrial disorder. The authors used the ND23 mutant for testing the hypothesis that anesthetics have toxic potential in carriers of mitochondrial mutations.

Methods

The authors exposed wild-type flies and ND23 mutant flies to behaviorally equivalent doses of isoflurane or sevoflurane in 5%, 21%, or 75% oxygen. The authors used percent mortality (mean ± SD,

SUBMITTER: Olufs ZPG 

PROVIDER: S-EPMC7494633 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature