Cell motility and migration as determinants of stem cell efficacy.

ABSTRACT:

Background

Stem cells` (SC) functional heterogeneity and its poorly understood aetiology impedes clinical development of cell-based therapies in regenerative medicine and oncology. Recent studies suggest a strong correlation between the SC migration potential and their therapeutic efficacy in humans. Designating SC migration as a denominator of functional SC heterogeneity, we sought to identify highly migrating subpopulations within different SC classes and evaluate their therapeutic properties in comparison to the parental non-selected cells.

Methods

We selected highly migrating subpopulations from mesenchymal and neural SC (sMSC and sNSC), characterized their features including but not limited to migratory potential, trophic factor release and transcriptomic signature. To

SUBMITTER: Danielyan L 

PROVIDER: S-EPMC7494685 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature