Ontology highlight
ABSTRACT:
SUBMITTER: Peng H
PROVIDER: S-EPMC7494742 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Peng Hui H Guo Qi Q Xiao Ye Y Su Tian T Jiang Tie-Jian TJ Guo Li-Juan LJ Wang Min M
Frontiers in cell and developmental biology 20200903
Osteogenesis and senescence of BMSCs play great roles in age-related bone loss. However, the causes of these dysfunctions remain unclear. In this study, we identified a differentially expressed <i>ASPH</i> gene in middle-aged and elderly aged groups which were obtained from GSE35955. Subsequent analysis in various databases, such as TCGA, GTEx, and CCLE, revealed that <i>ASPH</i> had positive correlations with several osteogenic markers. The depletion of mouse <i>Asph</i> suppressed the capacity ...[more]