Isolation of mesenchymal stem cells from Pap smear samples.

ABSTRACT:

Objective

Exploiting their ability to differentiate into mesenchymal lineages like cartilage, bone, fat, and muscle, and to elicit paracrine effects, mesenchymal stem cells (MSCs) are widely used in clinical settings to treat tissue injuries and autoimmune disorders. One of accessible sources of MSC is the samples used for Papanicolaou (Pap) test, which is a cervical screening method for detecting potentially pre-cancerous and cancerous alterations in the cervical cells and to diagnose genetic abnormalities in fetuses. This study aimed to identify and isolate the stem cells from Pap smear samples collected from pregnant women, and to trace the origin of these cells to maternal or fetal tissue, and characterize their stem cell properties.

Methods

To investigate the possibilit

SUBMITTER: Park J 

PROVIDER: S-EPMC7494764 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature