Discovery of Novel Type II Bacteriocins Using a New High-Dimensional Bioinformatic Algorithm.

ABSTRACT: Antimicrobial compounds first arose in prokaryotes by necessity for competitive self-defense. In this light, prokaryotes invented the first host defense peptides. Among the most well-characterized of these peptides are class II bacteriocins, ribosomally-synthesized polypeptides produced chiefly by Gram-positive bacteria. In the current study, a tensor search protocol-the BACIIα algorithm-was created to identify and classify bacteriocin sequences with high fidelity. The BACIIα algorithm integrates a consensus signature sequence, physicochemical and genomic pattern elements within a high-dimensional query tool to select for bacteriocin-like peptides. It accurately retrieved and distinguished virtually all families of known class II bacteriocins, with an 86% specificity. Further, the algorith

SUBMITTER: Yount NY 

PROVIDER: S-EPMC7494827 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature