Experimental autoimmune encephalomyelitis is associated with changes of the microbiota composition in the gastrointestinal tract.

ABSTRACT: The gut microbiome is known to be sensitive to changes in the immune system, especially during autoimmune diseases such as Multiple Sclerosis (MS). Our study examines the changes to the gut microbiome that occur during experimental autoimmune encephalomyelitis (EAE), an animal model for MS. We collected fecal samples at key stages of EAE progression and quantified microbial abundances with 16S V3-V4 amplicon sequencing. Our analysis of the data suggests that the abundance of commensal Lactobacillaceae decreases during EAE while other commensal populations belonging to the Clostridiaceae, Ruminococcaceae, and Peptostreptococcaceae families expand. Community analysis with microbial co-occurrence networks points to these three expanding taxa as potential mediators of gut microbiome dysbiosis.

SUBMITTER: Johanson DM 

PROVIDER: S-EPMC7494894 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature