A Distinct Brain-Gut-Microbiome Profile Exists for Females with Obesity and Food Addiction.

ABSTRACT:

Background

Alterations in brain-gut-microbiome interactions have been implicated as an important factor in obesity. This study aimed to explore the relationship between food addiction (FA) and the brain-gut-microbiome axis, using a multi-omics approach involving microbiome data, metabolomics, and brain imaging.

Methods

Brain magnetic resonance imaging was obtained in 105 females. FA was defined by using the Yale Food Addiction Scale. Fecal samples were collected for sequencing and metabolomics. Statistical analysis was done by using multivariate analyses and machine learning algorithms.

Results

Of the females with obesity, 33.3% exhibited FA as compared with 5.3% and 0.0% of females with overweight and normal BMI, respectively (P = 0.0001). Based on a multilevel spars

SUBMITTER: Dong TS 

PROVIDER: S-EPMC7494955 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature