Validation of Psychometric Properties of the Itch Numeric Rating Scale for Pruritus Associated With Prurigo Nodularis: A Secondary Analysis of a Randomized Clinical Trial.

ABSTRACT:

Importance

There is an unmet need for psychometrically sound instruments to measure pruritus associated with prurigo nodularis (PN).

Objective

To evaluate the psychometric properties of the itch numeric rating scale (itch NRS), both the Worst Itch Numeric Rating Scale (WI-NRS) and the Average Itch Numeric Rating Scale (AI-NRS).

Design, setting, and participants

This secondary analysis is based on a secondary end point of a phase 2 randomized clinical trial of serlopitant for treatment of pruritus associated with PN. This randomized, double-blind, placebo-controlled study was conducted at 15 sites in Germany. Eligible patients were aged 18 to 80 years and had generalized PN for more than 6 weeks that was refractory to previous antipruritic therapies. Patients were requ

SUBMITTER: Kimel M 

PROVIDER: S-EPMC7495327 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature