Effect of Prophylactic Embolization on Patients With Blunt Trauma at High Risk of Splenectomy: A Randomized Clinical Trial.

ABSTRACT:

Importance

Splenic arterial embolization (SAE) improves the rate of spleen rescue, yet the advantage of prophylactic SAE (pSAE) compared with surveillance and then embolization only if necessary (SURV) for patients at high risk of spleen rupture remains controversial.

Objective

To determine whether the 1-month spleen salvage rate is better after pSAE or SURV.

Design, setting, and participants

In this randomized clinical trial conducted between February 6, 2014, and September 1, 2017, at 16 institutions in France, 133 patients with splenic trauma at high risk of rupture were randomized to undergo pSAE or SURV. All analyses were performed on a per-protocol basis, as well as an intention-to-treat analysis for specific events.

Interventions

Prophylactic SAE, prefer

SUBMITTER: Arvieux C 

PROVIDER: S-EPMC7495330 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature