Modular and Selective Arylation of Aryl Germanes (C-GeEt₃ ) over C-Bpin, C-SiR₃ and Halogens Enabled by Light-Activated Gold Catalysis.

ABSTRACT: Selective C sp2 -C sp2 couplings are powerful strategies for the rapid and programmable construction of bi- or multiaryls. To this end, the next frontier of synthetic modularity will likely arise from harnessing the coupling space that is orthogonal to the powerful Pd-catalyzed coupling regime. This report details the realization of this concept and presents the fully selective arylation of aryl germanes (which are inert under Pd⁰ /Pd^II catalysis) in the presence of the valuable functionalities C-BPin, C-SiMe₃ , C-I, C-Br, C-Cl, which in turn offer versatile opportunities for diversification. The protocol makes use of visible light activation combined with gold catalysis, which facilitates the selective coupling of C-Ge with aryl diazonium salts. Contrary t

SUBMITTER: Sherborne GJ 

PROVIDER: S-EPMC7496160 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature