After-Effects of Time-Restricted Feeding on Whole-Body Metabolism and Gene Expression in Four Different Peripheral Tissues.

ABSTRACT:

Objective

Epidemiological studies show that shift workers are at increased risk for type 2 diabetes. As modern societies increasingly require shift work, it seems crucial to determine whether there are long-lasting health effects of rotational shifts.

Methods

This study examined the after-effects of 4 weeks of time-restricted feeding (TRF) during the light period (= light-fed) in rats, an animal model for shift work. This study also included a TRF-dark (= dark-fed) control group. The aligned and misaligned feeding times of light and dark feeding are associated with poor and good health outcomes, respectively. Several physiological measures were monitored continuously; blood, liver, brown adipose tissue, and soleus and gastrocnemius muscle were collected following 11 days of

SUBMITTER: de Goede P 

PROVIDER: S-EPMC7496197 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature