Integrin beta-3 genetic variants and risk of venous thromboembolism in colorectal cancer patients.

ABSTRACT:

Background

Integrin β3 is involved in tumor and endothelial cell biology as well as in platelet aggregation. Herein, we evaluated the predictive potential of three germline single nucleotide polymorphisms (SNPs) in the integrin β3 gene (rs3809865, rs5918 and rs4642) to predict the risk of venous thromboembolism (VTE) in colorectal cancer (CRC) patients, which is one of the leading causes of death among cancer patients.

Methods

112 patients diagnosed with CRC enrolled in the prospective Vienna Cancer and Thrombosis Study (CATS) were assessed with a median follow-up of 46 months. DNA was isolated from venous blood samples and SNPs were analyzed by the PCR-RFLP method.

Results

VTE occurred in 12% (n=13) of all patients. The SNPs rs5918 and rs4642 were not associated with

SUBMITTER: Bianconi D 

PROVIDER: S-EPMC7496222 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature