Shared Metabolic Profile of Caffeine in Parkinsonian Disorders.

ABSTRACT:

Objective

The objective of this study was to determine comprehensive metabolic changes of caffeine in the serum of patients with parkinsonian disorders including Parkinson's disease (PD), progressive supranuclear palsy (PSP), and multiple system atrophy (MSA) and to compare this with healthy control serum.

Methods

Serum levels of caffeine and its 11 downstream metabolites from independent double cohorts consisting of PD (n = 111, 160), PSP (n = 30, 19), MSA (n = 23, 17), and healthy controls (n = 43, 31) were examined by liquid chromatography-mass spectrometry. The association of each metabolite with clinical parameters and medication was investigated. Mutations in caffeine-associated genes were investigated by direct sequencing.

Results

A total of 9 metabolites detec

SUBMITTER: Takeshige-Amano H 

PROVIDER: S-EPMC7496239 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature