The prevalence of corneal abnormalities in first-degree relatives of patients with keratoconus: a prospective case-control study.

ABSTRACT:

Purpose

Although there is a high prevalence of keratoconus in the Middle East including Israel, limited data is available describing first-degree relatives of patients with sporadic keratoconus (KC) using Scheimpflug imaging. The purpose of this study is to accurately phenotype first-degree relatives of patients with sporadic KC in Israel using corneal tomography, which may help determine the genetic aetiology of KC.

Methods

First-degree relatives (N = 56) of 16 KC probands participated in this prospective case-control study. Healthy controls (N = 96) were from a previous study. Autorefraction, visual acuity, slit lamp biomicroscopy, retinoscopy, subjective refraction and Scheimpflug imaging (CSO Sirius Topographer) of keratoconus patients and their first-degree relatives we

SUBMITTER: Shneor E 

PROVIDER: S-EPMC7496242 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature