Dynamic oxygen changes during status epilepticus and subsequent endogenous kindling.

ABSTRACT: OBJECTIVE:Brain tissue oxygen (partial oxygen pressure [pO₂ ]) levels are tightly regulated to stay within the normoxic zone, with deviations on either side resulting in impaired brain function. Whereas pathological events such as ischemic attacks and brief seizures have previously been shown to result in pO₂ levels well below the normoxic zone, oxygen levels during prolonged status epilepticus (SE) and the subsequent endogenous kindling period are unknown. METHODS:We utilized two models of acquired temporal lobe epilepsy in rats: intrahippocampal kainic acid infusion and prolonged perforant pathway stimulation. Local tissue oxygen was measured in the dorsal hippocampus using an optode during and for several weeks following SE. RESULTS:We observed hyperoxia in the hip

SUBMITTER: Wolff MD 

PROVIDER: S-EPMC7496277 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature