Immunohistochemical distribution of 10 GABA_A receptor subunits in the forebrain of the rhesus monkey Macaca mulatta.

ABSTRACT: GABA_A receptors are composed of five subunits arranged around a central chloride channel. Their subunits originate from different genes or gene families. The majority of GABA_A receptors in the mammalian brain consist of two α-, two β- and one γ- or δ-subunit. This subunit organization crucially determines the physiological and pharmacological properties of the GABA_A receptors. Using immunohistochemistry, we investigated the distribution of 10 GABA_A receptor subunits (α1, α2, α3, α4, α5, β1, β2, β3, γ2, and δ) in the fore brain of three female rhesus monkeys (Macaca mulatta). Within the cerebral cortex, subunits α1, α5, β2, β3, and γ2 were found in all layers, α2, α3, and β1 were more concentrated in the inner and outer layers. The caudate/putamen

SUBMITTER: Sperk G 

PROVIDER: S-EPMC7496627 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature