The natural course of pregnancies in women with primary atypical haemolytic uraemic syndrome and asymptomatic relatives.

ABSTRACT: Pregnancy has been linked to various microangiopathies, including primary atypical haemolytic uraemic syndrome (aHUS). Complement dysregulation, often linked to rare variants in complement genes, is key for primary aHUS to manifest and may play a role in pregnancy complications of the mother and fetus. The burden of such complications is unknown, making counselling of women with primary aHUS and asymptomatic relatives difficult. We analyzed the maternal and fetal outcomes of 39 pregnancies from 17 women with primary aHUS and two asymptomatic relatives. Seven out of 39 pregnancies were complicated by pregnancy-associated aHUS. Five out of 32 pregnancies not linked to pregnancy-associated aHUS were complicated by pre-eclampsia or HELLP. Rare genetic variants were identified in 10 women (asym

SUBMITTER: Timmermans SAMEG 

PROVIDER: S-EPMC7496636 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature