Exploring the Relationship Between Morphine Concentration and Oversedation in Children After Cardiac Surgery.

ABSTRACT: Titrating analgesic and sedative drugs in pediatric intensive care remains a challenge for caregivers due to the lack of pharmacodynamic knowledge in this population. The aim of the current study is to explore the concentration-effect relationship for morphine-associated oversedation after cardiac surgery in children aged 3 months to 3 years. Data on morphine dosing, as well as morphine plasma concentrations, were available from a previous study on the pharmacokinetics of morphine after cardiac surgery in children. Oversedation was defined as scores below 11 on the validated COMFORT-behavioral scale. Population pharmacokinetic-pharmacodynamic modeling was performed in NONMEM 7.3. The probability of oversedation as a function of morphine concentration was best described using a step functio

SUBMITTER: Valkenburg AJ 

PROVIDER: S-EPMC7496665 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature