Toward precision therapeutics: general and specific factors differentiate symptom change in depressed adolescents.

ABSTRACT:

Background

The longitudinal course of multiple symptom domains in adolescents treated for major depression is not known. Revealing the temporal course of general and specific psychopathology factors, including potential differences between psychotherapies, may aid therapeutic decision-making.

Methods

Participants were adolescents with major depressive disorder (aged 11-17; 75% female; N = 465) who were part of the IMPACT trial, a randomized controlled trial comparing cognitive behavioral therapy, short-term psychoanalytic psychotherapy, and brief psychosocial intervention. Self-reported symptoms at baseline and 6, 12, 36, 52, and 86 weeks postrandomization were analyzed with bifactor modeling.

Results

General psychopathology factor scores decreased across treatment an

SUBMITTER: Aitken M 

PROVIDER: S-EPMC7496892 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature