The 3Ds in virus-like particle based-vaccines: "Design, Delivery and Dynamics".

ABSTRACT: Vaccines need to be rationally designed in order be delivered to the immune system for maximizing induction of dynamic immune responses. Virus-like particles (VLPs) are ideal platforms for such 3D vaccines, as they allow the display of complex and native antigens in a highly repetitive form on their surface and can easily reach lymphoid organs in intact form for optimal activation of B and T cells. Adjusting size and zeta potential may allow investigators to further fine-tune delivery to lymphoid organs. An additional way to alter vaccine transfer to lymph nodes and spleen may be the formulation with micron-sized adjuvants that creates a local depot and results in a slow release of antigen and adjuvant. Ideally, the adjuvant in addition stimulates the innate immune system. The dynamics of

SUBMITTER: Mohsen MO 

PROVIDER: S-EPMC7496916 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature