Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model.

ABSTRACT:

Background

Immune challenge is known to increase heat stroke risk, although the mechanism of this increased risk is unclear.

Objectives

We sought to understand the effect of immune challenge on heat stroke pathology.

Patients/methods

Using a mouse model of classic heat stroke, we examined the impact of prior viral or bacterial infection on hematological aspects of recovery. Mice were exposed to heat either 48 or 72 hours following polyinosinic:polycytidylic acid (poly I:C) or lipopolysaccharide injection, time points when symptoms of illness (fever, lethargy, anorexia) were minimized or completely absent.

Results

Employing multivariate supervised machine learning to identify patterns of molecular and cellular markers associated with heat stroke, we found that p

SUBMITTER: Proctor EA 

PROVIDER: S-EPMC7496969 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature