Functionalized Cannabinoid Subtype 2 Receptor Ligands: Fluorescent, PET, Photochromic and Covalent Molecular Probes.

ABSTRACT: Cannabinoid subtype 2 receptors (CB₂ Rs) are G protein-coupled receptors (GPCRs) belonging to the endocannabinoid system, a complex network of signalling pathways leading to the regulation of key physiological processes. Interestingly, CB₂ Rs are strongly up-regulated in pathological conditions correlated with the onset of inflammatory events like cancer and neurodegenerative diseases. Therefore, CB₂ Rs represent an important biological target for therapeutic as well as diagnostic purposes. No CB₂ R-selective drugs are yet on the market, thus underlining a that deeper comprehension of CB₂ Rs' complex activation pathways and their role in the regulation of diseases is needed. Herein, we report an overview of pharmacological and imaging

SUBMITTER: Basagni F 

PROVIDER: S-EPMC7497013 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature