Resistance to state transitions in responsiveness is differentially modulated by different volatile anaesthetics in male mice.

ABSTRACT:

Background

Recent studies point to a fundamental distinction between population-based and individual-based anaesthetic pharmacology. At the population level, anaesthetic potency is defined as the relationship between drug concentration and the likelihood of response to a stimulus. At the individual level, even when the anaesthetic concentration is held constant, fluctuations between the responsive and unresponsive states are observed. Notably, these spontaneous fluctuations exhibit resistance to state transitions R_st. Therefore, the response probability in each individual depends not just upon the drug concentration, but also upon responses to previous stimuli. Here, we hypothesise that R_st is distinct from drug potency and is differentially modulated by diffe

SUBMITTER: Wasilczuk AZ 

PROVIDER: S-EPMC7497031 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature