Human plasma biomarker responses to inhalational general anaesthesia without surgery.

ABSTRACT:

Background

Postoperative neurocognitive disorders may arise in part from adverse effects of general anaesthetics on the CNS, especially in older patients or individuals otherwise vulnerable to neurotoxicity because of systemic disease or the presence of pre-existing neuropathology. Previous studies have documented cytokine and injury biomarker responses to surgical procedures that included general anaesthesia, but it is not clear to what degree anaesthetics contribute to these responses.

Methods

We performed a prospective cohort study of 59 healthy volunteers aged 40-80 yr who did not undergo surgery. Plasma markers of neurological injury and inflammation were measured immediately before and 5 h after induction of general anaesthesia with 1 minimum alveolar concentration of

SUBMITTER: Deiner S 

PROVIDER: S-EPMC7497032 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature