Muscle-Specific Relation of Acetylcarnitine and Intramyocellular Lipids to Chronic Hyperglycemia: A Pilot 3-T ¹H MRS Study.

ABSTRACT:

Objective

Acetylcarnitine plays an important role in fat metabolism and can be detected in proton magnetic resonance spectra in skeletal muscle. An inverse relationship of acetylcarnitine to intramyocellular lipids and metabolic markers of chronic hyperglycemia has been suggested. This study aimed to compare the acetylcarnitine concentrations and intramyocellular lipids measured noninvasively by proton magnetic resonance spectroscopy (¹H MRS) in the tibialis anterior and the soleus of three different groups of volunteers with a broad range of glycemic control.

Methods

Acetylcarnitine and intramyocellular lipid concentrations were measured in 35 individuals stratified into three groups according to glucose tolerance and/or manifestation of type 2 diabetes mellitus.

SUBMITTER: Klepochova R 

PROVIDER: S-EPMC7497241 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature