Granzyme B PET Imaging of Immune Checkpoint Inhibitor Combinations in Colon Cancer Phenotypes.

ABSTRACT:

Purpose

Immune checkpoint inhibitor (ICI) monotherapy and combination regimens are being actively pursued as strategies to improve durable response rates in cancer patients. However, the biology surrounding combination therapies is not well understood and may increase the likelihood of immune-mediated adverse events. Accurate stratification of ICI response by non-invasive PET imaging may help ensure safe therapy management across a wide number of cancer phenotypes.

Procedures

We have assessed the ability of a fluorine-labelled peptide, [¹⁸F]AlF-mNOTA-GZP, targeting granzyme B, to stratify ICI response in two syngeneic models of colon cancer, CT26 and MC38. In vivo tumour uptake of [¹⁸F]AlF-mNOTA-GZP following ICI monotherapy, or in combination with PD-1

SUBMITTER: Goggi JL 

PROVIDER: S-EPMC7497445 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature