Lactate Production Precedes Inflammatory Cell Recruitment in Arthritic Ankles: an Imaging Study.

ABSTRACT:

Purpose

Inflammation is involved in many disease processes. However, accurate imaging tools permitting diagnosis and characterization of inflammation are still missing. As inflamed tissues exhibit a high rate of glycolysis, pyruvate metabolism may offer a unique approach to follow the inflammatory response and disease progression. Therefore, the aim of the study was to follow metabolic changes and recruitment of inflammatory cells after onset of inflammation in arthritic ankles using hyperpolarized 1-¹³C-pyruvate magnetic resonance spectroscopy (MRS) and ¹⁹F magnetic resonance imaging (MRI), respectively.

Procedure

Experimental rheumatoid arthritis (RA) was induced by intraperitoneal injection of glucose-6-phosphate-isomerase-specific antibodies (GPI) c

SUBMITTER: Neveu MA 

PROVIDER: S-EPMC7497460 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature