Antibody-Enabled Antimicrobial Nanocapsules for Selective Elimination of Staphylococcus aureus.

ABSTRACT: Targeted bactericide nanosystems hold significant promise to improve the efficacy of existing antimicrobials for treatment of severe bacterial infections, minimizing the side effects and lowering the risk of the development of antibiotic resistance. In this work, we developed antibody-functionalized nanocapsules (NCs) containing antibacterial essential oil (EO) for selective and effective eradication of Staphylococcus aureus. Antibacterial EO NCs were produced via self-assembly nanoencapsulation in the plant-derived protein zein. The obtained EO NCs were decorated with aminocellulose to provide more reactive surface groups for carboxyl-to-amine immobilization of a antibody that is specific against S. aureus. The antibody-enabled EO NCs (Ab@EO NCs) demonstrated 2-fold higher b

SUBMITTER: Ivanova K 

PROVIDER: S-EPMC7497629 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature