Dynamics of Ionic Interactions at Protein-Nucleic Acid Interfaces.

ABSTRACT: Molecular association of proteins with nucleic acids is required for many biological processes essential to life. Electrostatic interactions via ion pairs (salt bridges) of nucleic acid phosphates and protein side chains are crucial for proteins to bind to DNA or RNA. Counterions around the macromolecules are also key constituents for the thermodynamics of protein-nucleic acid association. Until recently, there had been only a limited amount of experiment-based information about how ions and ionic moieties behave in biological macromolecular processes. In the past decade, there has been significant progress in quantitative experimental research on ionic interactions with nucleic acids and their complexes with proteins. The highly negatively charged surfaces of DNA and RNA electrostatically

SUBMITTER: Yu B 

PROVIDER: S-EPMC7497705 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature