The importance of patients' case-mix for the correct interpretation of the hospital fatality rate in COVID-19 disease.

ABSTRACT:

Objective

We aimed to document data on the epidemiology and factors associated with clinical course leading to death of patients hospitalised with COVID-19.

Methods

Prospective observational cohort study on patients hospitalised with COVID-19 disease in February-24th/May-17th 2020 in Milan, Italy. Uni-multivariable Cox regression analyses were performed. Death's percentage by two-weeks' intervals according to age and disease severity was analysed.

Results

A total of 174/539 (32.3%) patients died in hospital over 8228 person-day follow-up; the 14-day Kaplan-Meier probability of death was 29.5% (95%CI: 25.5-34.0). Older age, burden of comorbidities, COVID-19 disease severity, inflammatory markers at admission were independent predictors of increased risk, while several

SUBMITTER: d'Arminio Monforte A 

PROVIDER: S-EPMC7497732 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature