Predictors of Outcomes of COVID-19 in Patients With Chronic Liver Disease: US Multi-center Study.

ABSTRACT:

Background & aims

Chronic liver disease (CLD) represents a major global health burden. We undertook this study to identify the factors associated with adverse outcomes in patients with CLD who acquire the novel coronavirus-2019 (COVID-19).

Methods

We conducted a multi-center, observational cohort study across 21 institutions in the United States (US) of adult patients with CLD and laboratory-confirmed diagnosis of COVID-19 between March 1, 2020 and May 30, 2020. We performed survival analysis to identify independent predictors of all-cause mortality and COVID-19 related mortality, and multivariate logistic regression to determine the risk of severe COVID-19 in patients with CLD.

Results

Of the 978 patients in our cohort, 867 patients (mean age 56.9 ± 14.5 years, 55% m

SUBMITTER: Kim D 

PROVIDER: S-EPMC7497795 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature