Genetic diversity and epidemiology of accessory gene regulator loci in Clostridioides difficile.

ABSTRACT: Quorum sensing is known to regulate bacterial virulence, and the accessory gene regulator (agr) loci is one of the genetic loci responsible for its regulation. Recent reports examining Clostridioides difficile show that two agr loci, agr1 and agr2, regulate toxin production, but the diversity of agr loci and their epidemiology is unknown. In our study, in silico analysis was performed to research genetic diversity of agr, and C. difficile isolates from clinical samples underwent multilocus sequence typing (MLST) and PCR analysis of agr loci. To reveal the distribution of agr among different strains, phylogenetic analysis was also performed. In our in silico analysis, two different subtypes, named agr2R</

SUBMITTER: Okada Y 

PROVIDER: S-EPMC7497831 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature