Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function.

ABSTRACT:

Background

Platelets play a pivotal role in hemostasis, wound healing, and inflammation, and are thus implicated in a variety of diseases, including cancer. Platelet function is associated with release of granule content, cellular shape change, and upregulation of receptors that promote establishment of a thrombus and maintenance of hemostasis.

Objectives

The role of heat shock proteins (Hsps) in modulating platelet function has been studied for a number of years, but comparative roles of individual Hsps have not been thoroughly examined.

Methods

We utilized a panel of specific inhibitors of Hsp40, Hsp70, Hsp90, and Grp94 (the endoplasmic reticulum homolog of Hsp90) to assess their impact on several aspects of platelet function.

Results

Inhibition of each of th

SUBMITTER: Jackson JW 

PROVIDER: S-EPMC7497839 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature