Physiological effects of subthalamic nucleus deep brain stimulation surgery in cervical dystonia.

ABSTRACT:

Background

Subthalamic nucleus deep brain stimulation (STN DBS) surgery is clinically effective for treatment of cervical dystonia; however, the underlying physiology has not been examined. We used transcranial magnetic stimulation (TMS) to examine the effects of STN DBS on sensorimotor integration, sensorimotor plasticity and motor cortex excitability, which are identified as the key pathophysiological features underlying dystonia.

Methods

TMS paradigms of short latency afferent inhibition (SAI) and long latency afferent inhibition (LAI) were used to examine the sensorimotor integration. Sensorimotor plasticity was measured with paired associative stimulation paradigm, and motor cortex excitability was examined with short interval intracortical inhibition and intracortical

SUBMITTER: Wagle Shukla A 

PROVIDER: S-EPMC7498178 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature