Targeting SARS-CoV-2 Main Protease: A Computational Drug Repurposing Study.

ABSTRACT:

Background and aims

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) induced Novel Coronavirus Disease (COVID-19) has currently become pandemic worldwide. Though drugs like remdesivir, favipiravir, and dexamethasone found beneficial for COVID-19 management, they have limitations clinically, and vaccine development takes a long time. The researchers have reported key proteins which could act as druggable targets. Among them, the major protease M^pro is first published, plays a prominent role in viral replication and an attractive drug-target for drug discovery. Hence, to target M^pro and inhibit it, we accomplished the virtual screening of US-FDA approved drugs using well-known drug repurposing approach by computer-aided tools.

Methods

The prot

SUBMITTER: Baby K 

PROVIDER: S-EPMC7498210 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature