An NMR-based approach reveals the core structure of the functional domain of SINEUP lncRNAs.

ABSTRACT: Long non-coding RNAs (lncRNAs) are attracting widespread attention for their emerging regulatory, transcriptional, epigenetic, structural and various other functions. Comprehensive transcriptome analysis has revealed that retrotransposon elements (REs) are transcribed and enriched in lncRNA sequences. However, the functions of lncRNAs and the molecular roles of the embedded REs are largely unknown. The secondary and tertiary structures of lncRNAs and their embedded REs are likely to have essential functional roles, but experimental determination and reliable computational prediction of large RNA structures have been extremely challenging. We report here the nuclear magnetic resonance (NMR)-based secondary structure determination of the 167-nt inverted short interspersed nuclear element (SI

SUBMITTER: Ohyama T 

PROVIDER: S-EPMC7498343 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature